Fibrin and Multiple Sclerosis
Fibrin production is a completely normal, and in fact, important, biological process. When we get hurt, it is fibrin that develops around the wound, creating a mesh that soon dries and hardens. Fibrin is a highly important human response to injury, however, what if the presence of fibrin in the body is too high? What type of risk factors might this pose? Researchers are beginning to find that excess fibrin may be to blame for conditions such as Multiple Sclerosis.
MS is an autoimmune disease that affects the central nervous system (CNS), causing a variety of symptoms including loss of balance and muscle coordination, changes in cognitive function, slurred speech, bladder and bowel dysfunction, pain, and diminished vision. While the exact cause of MS is unknown, a hallmark of the disease is the loss of a material called myelin that coats nerve fibers, and the inability of the body's natural processes to repair the damage.1
Researchers in California have determined that fibrin depletion decreases multiple sclerosis symptoms.
"Tissue damage due to Multiple Sclerosis (MS) is reduced and lifespan lengthened in mouse models of the disease when a naturally occurring fibrous protein called fibrin (the yellow substance seen in the above picture) is depleted from the body, according to researchers at the University of California, San Diego (UCSD) School of Medicine."
The study, reported online the week of April 19, 2004 in the Proceedings of the National Academy of Sciences, identifies fibrin as a potential target for therapeutic intervention in the disease, which affects an estimated one million people worldwide.
"Multiple sclerosis is a nervous system disease with vascular damage, resulting from the leakage of blood proteins, including fibrin, into the brain," said the study's first author, Katerina Akassoglous, Ph.D., a UCSD School of Medicine assistant professor of pharmacology. "Our study shows that fibrin facilitates the initiation of the inflammatory response in the nervous system and contributes to nerve tissue damage in an animal model of the disease."
Although fibrin is best known for its important role in blood clotting, recent studies have shown that fibrin accumulates in the damaged nerves of MS patients, followed by a break down of myelin.1
Discovery Health Channel host and chartered biologist Dr. Laz Bannock demonstrated this when he conducted a six-month clinical trial of Neprinol. According to Dr. Bannock "unlike taking daily aspirin, which is an over the counter drug, Neprinol is a nutritional supplement that helps the body to maintain already healthy fibrin expression and inflammation levels."
Neprinol AFD (Advanced Fibrin Defense), from Arthur Andrew Medical, offers great new alternatives for MS sufferers. Neprinol's composition of systemic enzymes nattokinase and serrapeptase, have been clinically shown to safely modulate the body's own fibrin production. This could offer great hope to those who already, or soon may, suffer from MS symptoms.
Neprinol is available now without a doctor's prescription at Fibromedica Health Solutions. For more information on Neprinol and Dr. Bannocks case studies, please read more at our case studies homepage: http://www.fibromedica.com/case_study_intro.
For the complete UCSD study on fibrin and Multiple Sclerosis click here.
1. Pondrom, Sue. Eurekalert! http://www.innovationsreport.com/html/reports/medicine_health/report-28229.html.
2. Bannock, Laz. "The Doctor's Prescription for Healthy Living." Sources available at http://www.freedompressonline.com/